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thank you rudy once again i want to.welcome all of you to this open session.of the national advisory human genome.research meeting.as you can see the current situation.with the kova 19 pandemic has.led me to present my director's report.while sitting alone.in my conference room um in addition and.to accommodate a.shorter council meeting my director's.report is a bit shorter than the norm.nonetheless we believe it contains an.informative collection of updates that.we wanted to share.with you and as with the rest of the.open session my director's report.presentation is being videotaped and.that recording will be made.available as a permanent archive on.nhgri's website.genome.gov now for those new to council.meetings.i just want to make you aware that.there's an electronic resource that gets.developed by staff.for my director's report which is.analogous to a supplemental materials of.a published paper.uh this resource can be accessed at the.url.shown at the bottom of the slide.meanwhile the slides that i'm going to.show during my directors report.are available for downloading um and you.can access those slides also at this.site.actually in two formats both pdf and.powerpoint formats.and then when there's relevant documents.or relevant websites associated with a.particular slide you will see a document.number indicated on the bottom right.corner of the slide and that document.number references materials that can be.accessed and or.downloaded from this webpage now this.dedicated web page and.all of the linked documents will be.archived on genome.gov.as part of the historic record of this.council meeting.now there will be a number of other.presentations during the open session of.this council meeting i deliberately.have tailored my director's report.around these presentations so i'm not.going to discuss in detail any of the.topics.that others will cover following my.director's report we'll have a special.guest mike lauer who's the nih deputy.director for extramural research.uh we'll give a presentation on foreign.infra influences on research integrity.nih experience and advice.next nhgri extramural program director.luis cubano will present a concept.clearance.on two related training proposals.uh one a pre-doctoral to post doctoral.transition award f99k00 promote.diversity.and one on a short-term research career.enhancement award for established.investigators k-18.to promote diversity.and then two final presentations will.follow.one by eleanor carlson a director of.vertebrate genomics group at the broad.institute of mit and harvard on.perspectives in comparative genomics and.evolution.and one by our own larry brody who's.director of nhgri's.division of genomics and society on elsi.research.activities across nih.so for the rest of my directions report.i will cover the seven areas listed here.which have consistently.provided a nice framework for me to be.able to cover.all the material that we wanted to.summarize for you and we will start with.some general nhgri updates.it's really with great pleasure that i.announced the appointment.of aaron ramos as the new deputy.director of nhgri's division of genomic.medicine.erin joined nhgri in 2007 shortly after.completing her phd in public health.genetics at the university of washington.soon after her arrival she stepped up to.design and launch the phenotypes and.exposures or.phoenix toolkit she later established.and co-chaired the first trans-nih data.access committee.for the genetic association information.network or gain.which provided access to some of the.first genome-wide association studies.available in dbgap.even today aaron continues to play a key.role.in data sharing policy and.implementation as co-chair of nhgri's.data genomic data sharing governance.committee.and then in 2012 aaron led the.establishment.of the clinical genome resource or.clingen an authoritative central.resource for establishing the clinical.relevance of genes and genomic variants.for use in precision medicine and.research and so congratulations to aaron.being appointed the new deputy director.of the division of genomic medicine.renee sterling is a new program director.in nhgri's division of genomics and.society.rene is a postdoctoral graduate of one.of our centers.for excellence and elsie research where.she focused on public opinion.direct-to-consumer marketing and.biobanking.she has over 15 years of federal service.with one of nih's sister agencies.the health resources and services.administration or ursa.where she held program officer senior.advisor.and deputy director positions through.this work she has acquired expertise in.healthcare and public health systems.health policy and health disparities.rene will manage a portfolio of grants.within the ethical legal and social.implications or lc research program.and advise on related matters.nhgri's division of genomics as society.partners with the american society of.human genetics or ashg.and sponsoring two fellowships each year.the genetics and public policy.fellowship provides fellows an.opportunity to work in nhgri's policy.and program analysis branch.at nh at ashg and in congress.this year's fellow is emma alma.emma recently completed her phd in.biochemistry and molecular biology at.the university of california.san francisco the genetics.and education fellowship program.provides fellows an opportunity to work.in nhgri's.education and community involvement.branch and at ashg.in developing educational programs for a.wide range of audiences.the fellow may also do a rotation with a.public or a private organization.involved in genetics and genomics.research.and education this year's fellow is.tiffany.roll tiffany recently completed her phd.in molecular and human genetics from.baylor college of medicine.now as a reminder october 1 2020 just a.few weeks away a couple weeks at this.point will mark the official.30th anniversary of the launch of the.human genome project.recognizing the significance of this.milestone.nhgri's history of genomics program and.our communications and public liaison.branch.have been busy producing outreach.materials to commemorate this.anniversary.and to celebrate the human genome.project and its legacy.starting back in march we have been.showcasing 30 of our oral histories with.prominent genomicists.specifically highlighting one per week.for 30 weeks.leading up to the 30th anniversary.itself some of the interviewees.are shown here then in october.there will be an extensive social media.campaign for the 30th anniversary.that will feature video testimonials.about the impact of the human genome.project.for many genomics and genetics.researchers.a preview of the testimonial from none.other than francis collins is shown here.as a teaser.nhgri is recording some of the.testimonials for this campaign.but we will also be encouraging others.to make their own videos.that we will then post on the nhgri.twitter feed.the highlight of our commemoration of.the 30th anniversary of the human genome.project's launch.next month will be the publication of.the 2020.nhgri strategic vision.recall that nhgri embarked on a new.strategic planning process in 2018 which.we dubbed.genomics 2020. that process involved.over 50 events with numerous.stakeholders and communities.as well as extensive engagement with all.of the institute's advisory groups in.particular this.advisory council many nhgri staff.members.work tirelessly to collect input along.the way and to synthesize that input.into a compelling and informative vision.for the future of human genomics.we released a draft version of the.strategic vision.manuscript back in april and received.extensive.in feedback that allowed us to refine it.further.the manuscript was then submitted for.publication in mid-summer.and i am pleased to say that this paper.entitled strategic vision for improving.human health.at the forefront of genomics is now in.press in the journal nature.and will be published in late october.shown here is the centerpiece figure.from that paper.which depicts the four major areas of.the new strategic vision.i wanted to give my profound thanks to.many of you both.inside and outside of the institute who.contributed.to the genomics 2020 strategic planning.process.and then the crafting of the 2020.strategic vision paper.a special shout out to all of the.current and former advisory council.members who for the past two plus years.have provided invaluable advice input.and encouragement and with that i will.move on to some general nih.updates let me just start by pointing.out that despite.the covet 19 pandemic francis collins.has been just simply amazing at.successfully completing recruitments for.new institute directors to nih.with five being announced since the last.council meeting in may.for starters and shown here rick.whitchuck who's familiar to many of us.in the genetics and genomics community.has now been appointed the director of.the national institute of environmental.health sciences or niehs.rick joined niehs in 2010 as the.institute's deputy director.and then served as its acting director.starting in october of 2019..his appointment as niehs director began.in early june.located in research park research.triangle park north carolina niehs.conducts and supports environmental.health sciences and alignment with real.world public health needs.and translates science findings into.knowledge that can inform real life.individual and public health outcomes.shannon zink who has been has been.selected as the new director of the.national institute of nursing research.or ninr.shannon a registered nurse and leading.nurse researcher is currently.a nursing collegiate professor in the.department of population health nursing.science at the university of illinois.at chicago's college of nursing.her research focuses on social.inequities and health with the goal of.identifying effective.multi-level approaches to improve health.and eliminate racial.ethnic and socio-economic health.disparities.she will begin in her new role as the.ninr director.later this year.michael chiang has been selected as the.new director of the national eye.institute or nei.a practicing ophthalmologist michael is.currently the knowles professor of.ophthalmology and medical informatics.and clinical epidemiology.at oregon health science health and.science university.and is associate director of the.university's kci.institute his research focuses on.telemedicine and artificial intelligence.for diagnosis of retinopathy of.prematurity and other ophthalmic.diseases.implementation and evaluation of.electronic health record systems.and modeling of clinical workflow and.data analytics.he will begin his new role as the nei.director later this year.lindsey criswell has been selected as.the new director of the national.institute of arthritis and.musculoskeletal and skin diseases or.niams.lindsey is a rheumatologist with.experience as a clinician researcher and.administrator.she currently serves as the vice.chancellor of research at the university.of california san francisco.where she is also professor of.rheumatology in the university's.department of medicine.as well as a professor of oral facial.sciences in its school of dentistry.her research focuses on the epidemiology.and genetics of human autoimmune.diseases.particularly rheumatoid arthritis and.systemic lupus erythematosus.she will begin her new role as the niams.director.in early 2021.and finally rene d'souza has been.selected as the new director of the.national institute of dental.and cranial facial research or nidcr.raynor currently serves as the assistant.vice president for academic affairs and.education.for health sciences at the university of.utah there she also serves as a.professor of dentistry.the olin marty jensen chair of the.school of dentistry.and professor of neurobiology and.anatomy pathology and surgery in the.school of medicine and the department of.biomedical engineering.she is a devoted mentor and champion of.diversity in the biomedical.research workforce she will begin her.new role as the ni dcr director.later this year.so those are the arrivals uh there are.departures.or in particular one later this month.unfortunately hannah valentine.good friend of the institutes will.retire from nih.as the chief officer for scientific.workforce diversity hannah joined nih in.the spring of 2014..since then she has worked to develop and.implement a comprehensive strategy.for promoting inclusiveness and equity.at nih and throughout the biomedical.research enterprise her accomplishments.include establishing the nih.distinguished scholars program creating.the nih.equity committee developing and.implementing the first nih workplace.climate and harassment survey.designing the faculty institutional.recruitment and sustainability.transformation or.first program and guiding the national.research mentoring network.she has also led a highly productive.research program within the national.heart lung and blood institute.after departing nih hannah will return.to california.stanford university and her family.meanwhile marie bernard who's the deputy.director of the national institute on.aging will serve as the acting chief.officer for.scientific workforce diversity while the.search for a permanent successor.successor is conducted.the american association for cancer.research or aacr.recently recognized the cancer genome.atlas or.tcga through the aacr 2020 team science.awards.specifically awards were given to the.founding members of tcga and the current.project team.both groups were recognized during the.aacr virtual annual meeting.in late june now tcga was a coordinated.program led jointly by nhgri and the.national cancer institute.which brought together researchers from.diverse scientific disciplines and.multiple institutions.to create a detailed catalog of genomic.modifications associated with specific.types of cancer.tcga has played a major role in.advancing cancer genomics as.illustrated by the tcga publications.highlighted in this.figure the individual recognized.as part of these 2020 team science.awards.include current nhgri staff members.carolyn hutter.and heidi sofia as well as former nhgri.staff members jane peterson.mark guyer peter good and brad.osenberger.and then in may nih director and nhgri.senior investigator in our intramural.research program francis collins.was named the recipient of the templeton.prize for 2020..the templeton prize is an annual award.given to a person who.quote whose exemplary achievements.advance sir john teppelton's.philanthropic vision.harnessing the power of the sciences to.explore the deepest questions of the.universe.and humans kinds place and purpose.within it.end of quote congratulations francis.i would like to remind you that several.government websites are available that.provide relevant information about covit.19.such as those at the centers for disease.control and prevention.and at nih specifically for nih.grantees and applicants a covit 19.resource is available on the nih grants.and funding website.in addition nih regularly issues news.releases regarding covet 19 related.research findings.and finally the nih director francis.collins's blog.provides another good source of updated.information.and finally in terms of nih updates it.is.obviously an interesting time on capitol.hill.congress is facing an election year is.trying to pass.another covet 19 related supplemental.spending package.and is also hoping to pass a fiscal year.2021 budget.all of this before both chambers leave.in mid-october.to go campaign through election day.government funding will run out.september 30th unless a budget.or a continuing resolution that is a cr.is passed.as of now the new budget or a new budget.is uncertain since congress is focusing.on cobig 19.relief packages there have been.discussions of attaching a cr.to the covet 19 relief package or.passing a cr separately.additionally the length of the cr is yet.to be determined.with the expectation being that it would.run at least through the election.but there is much debate about how much.past the election acr might extend.still there was movement in the house on.a fiscal year 2021 labor hhs spending.package.earlier this summer the house proposed.an.increase for nih of 275 million or about.a 0.65 percent increase.uh this would give nhgri an additional.six million or about a one percent.increase.but the house appropriations bill also.includes five.billion dollars of emergency funds to.help address the negative consequences.of the covet-19 pandemic.on the biomedical research enterprise.these emergency funds would be available.for use.through fiscal year 2025..furthermore that house bill stipulates.that these emergency funds would provide.each nih institute.and center a seven percent increase in.funding for fiscal year 2021..now we have yet to see language from the.senate side.though and there are many steps before a.final fiscal year 2021 budget.may be passed so needless to say stay.tuned.moving on then to general genomics.updates.beverly hagan a long time researcher at.the jackson laboratory.sadly passed away in june at the age of.81..she died a few months after the passing.of her husband ken pagan.also a long-time jackson lab researcher.and the laboratory's director through.the 1990s.beverly revolutionized the study of.heart disease and pioneered the.promotion.of the mouse for cardiovascular research.her research into the love canal toxic.waste dump in new york state.has been credited with spurring the.creation of the federal superfund.program.she was also an early adopter of.computational biology.and statistical genetics.our colleagues at the american society.of human genetics ashg have worked with.my senior advisor chris gunter.and her role as the chair of the ashg.online programs and professional.education working group.to create a podcast series each podcast.features chris in a 15 to 20 minute.informal conversation with an ashg.member.about their career in genetics four.examples are shown on the right.the importance of mentoring has been a.common theme throughout these initial.episodes.as has the reality of career paths that.go in directions that were never.expected.listeners were here about the amazing.work being done by these interviewees.their past that got them to where they.are now and their personal lives.outside the lab including what it is.like to be featured in a pbs documentary.from council member wendy chung the.episodes are free with registration on.the ashg.website in july.the national academies of sciences.engineering and medicine or.nascm published a report from a workshop.sponsored by the national science.foundation on.next steps for functional genomics the.workshop was held to determine research.needs to advance the field.of functional genomics across the life.sciences over the next 10.to 20 years.and then last week the national academy.of medicine the national academy of.sciences and the royal society.released a consensus report entitled.heritable human.genome editing the report is a.culmination of a year of work by the.international commission on the clinical.use of human genome editing.and describes the state of the science.finding that heritable human genome.editing.cannot currently be performed safely and.should not be attempted.until safety and efficacy are.established.the report also provides a framework for.scientists clinicians and regulatory.authorities to consider when assessing.clinical applications of heritable human.genome editing.should a country ultimately decide to.permit it.earlier this summer the foundation for.the national institutes of health or.fnih.named former council member of e verge.the winner.of the 2020 lurie prize in biomedical.sciences for laying the foundation for.the field of single cell genomics.spearheading leading-edge technologies.that enable a sharper perspective.on human cells and applying those.technologies to revolutionize our.understanding.of biology and disease so.congratulations to aviv.and finally i should point out to you.that.this past june june 26 specifically.marked the 20th anniversary of that.famous white house event.at which president bill clinton.announced the completion.of a draft sequence of the human genome.that day will always have a special.place in nhgri's history.and so to commemorate the event nhgri's.communication and public liaison branch.developed a dedicated web.and social media content which guarded.over 5000 views.the content included written memories of.former nhgri.staff and human genome project.researchers who were present.at the white house event on that day.moving on then to the nhgri extramural.research program.nhgri's technology development program.supports the development of new and.innovative technologies to enable.genomic discoveries and to accelerate.accelerate the adoption of genomics in.medicine.through funding opportunity.announcements nhgri continues to fund.novel genomic technology development.work to catalyze.major advances in genomics beyond.nucleic acid sequencing.applications for this funding.opportunity are due on october 2nd.the program's newest funding opportunity.is for novel synthetic nucleic acid.technology development the purpose of.this effort is to improve the quality.compatibility and efficiency of nucleic.acid.synthesis and production of synthetic.constructs at reasonable.and decreased costs applications for.this funding opportunity.are due on february 1st of 2021..the program hosted the advanced genomic.technology development meeting 2020.through virtual means this past may the.meeting included a session on the.application of genomic technologies to.covet 19.talks from grantees and trainees on.their technology development.innovation and development work and.trainee career development sessions.aimed to establish and improve.scientific collaborations.foster data sharing and exchange and.provide.information on funding the next career.steps.the goal of the encyclopedia of dna.elements or encode project is to create.catalogs of all functional elements in.the human and mouse genomes and to make.those catalogs freely available as a.resource.to the biomedical research community the.encode phase 3 consortium.published a package of papers in late.july which featured 14.papers in nature and other major.journals.these papers are a subset of over 500.encode consortium papers published.during encode phase 3..the package featured a main paper that.highlights the expansion of encode's.catalog.identifying candidates regulatory.elements and creating a comprehensive.registry of these elements.during encode phase 3 the search.candidate.cis regulatory elements by encode tool.otherwise known as screen was developed.as a user-friendly way to navigate the.extensive catalog.the consortium also published a.perspective of encode.paper and perspectives of encode paper.which provides an overview of the.history of the project and its growth.during phase three.reflections on the impact of encode and.also talked about.future directions the package.contains additional publications.spanning topics of human.and mouse gene expression regulation.epigenetics human disease.and software tools.the encode consortium will hold a.virtual research applications and users.meeting from september 30th.to october 2nd the meeting will be held.at times compatible for both u.s and.european participants.and the sessions will be recorded to.broaden access to this meeting.the goal is to expose new users to.encode and to provide them with skills.to use encode data with guidance from.current consortium members.planned workshops include an.introduction to the encode portal.navigating the encode encyclopedia with.screen.and an interactive introduction to.factor book which provides information.about transcription factor binding sites.in various biological contexts.registration for this meeting is open.and can be completed via the meeting.website.which is in code2020.org.nhgri is launching a new initiative in.functional genomics called.the impact of genomic variation on.function.or igvf program this program aims to.develop a framework for systematically.understanding the effects of genomic.variation on genome function.and how these effects shape phenotypes.the igvf program will consist of five.interrelated components.that will use emerging experimental and.computational approaches to build a.catalog.of the impact of genomic variants on.genome function and phenotypes.five new funding opportunities are now.published.in the following areas systematic.characterization of genomic variation on.genome function and phenotype.defining genomic influence on gene.network regulation.single cell profiling of regulatory.element and gene activity in.relationship to genome function.genomic variation and functional data.and administrative coordinating center.and developing predictive models of the.impact of genomic variation.on genome function nhgri.especially encourages applicants who are.new investigators.experienced investigators new to.genomics investigators who have not.previously participated in an nhgri.consortium.or program and investigators from.demographic groups or institutions that.are considered.underrepresented in genomics.applications for all five funding.opportunities are due.november 4th of this year the centers of.excellence in genomic science or sex.program supports the interdisciplinary.research teams.that are involved in developing highly.innovative approaches in genomics.research.the fiscal year 2020 nhgri appropriation.included 10 million dollars.for a new competitively awarded.center-based grant program.for emerging centers of excellence or.e-sex.in response nhgri issued a first a first.notice of change for fiscal year 2020 to.amend the original announcement for the.sex program.and to allow an opportunity for.institutions that are not.previous sex grantees to apply for sex.fundings.sex funding which would be executed as.part of the program balance criterion.when making funding decisions nhgri.has now issued a second notice of change.for fiscal year 2021.to fund another round of e-segs.specifically we added an additional.receipt date in november 2020.and again emphasized our interest in.applicants.from institutions that are not previous.sags grantees.the sex program will continue to.encourage submission of outstanding and.innovative applications from all.eligible institutions and we have.applications under review for the.regular sex program.and the next receipt date in may 2021.will not change.the developmental genotype tissue.expression or.dg tax project is a new initiative.that will be co-led by nhgri and the.national institute of child health and.human development.the goal of dgtx is to catalog and.analyze.transcriptional profiles from a wide.variety of tissues obtained from.neonates.children and adolescents in a postmortem.setting.the aims of the project are to create an.atlas of gene expression and biobank on.bulk tissues.and and in single cells to analyze.differences in gene expression across.developmental stages.and to develop an lc research program.two companion.d gtex requests for applications were.recently released.the laboratory data analysis and.coordinating center will perform two.major functions.serve one serve as a molecular.laboratory and perform basic analyses of.genotyping and expression data at the.tissue and single cell levels.for public release and to serve as a.coordinating.center to help monitor study progress.and laboratory performance.the biospecimen procurement center will.procure tissue from pediatric donors and.provide high quality tissue samples for.genomic analyses.applications are due on november 13th.and december 3rd respectively.for these two funding opportunities.in september 2018 nhgri established the.analysis.visualization and informatics lab space.or anvil.anvil is a cloud-based infrastructure.and software platform that provides.an analysis and computing environment.for unrestricted.and controlled access genomic and.phenotype data sets.this past june the anvil training team.hosted the massive genome informatics in.the cloud or.magic jamboree for nhgri's genome.sequencing program researchers.the event included an introduction.focused on how to use the anvil platform.and tools to analyze.genome sequencing program data.there will be opportunities to learn.more about anvil through.workshops at the virtual 2020 american.society of human genetics or shg meeting.next month.specifically the anvil team will be.leading workshops focused on.how to perform gwas analyses with galaxy.and anvil.and how to find and analyze cloud data.with the.gen 3 dock store and terra platforms.finally anvil is a designated repository.for the covid19.host genetics initiative or hgi data.from u.s contributors the purpose of hgi.is to share and analyze data to learn.the genetic determinants of covid19.susceptibility.severity and outcomes.the genome-wide association studies or.gwas catalog is a collaborative project.between the european bioinformatics.institute ebi.and nhgri the catalog provides a.searchable and freely available database.of snipped trait associations for.scientists clinicians and.other users worldwide staff.associated with the g-wasp catalog.organized a community workshop.entitled gy summary statistics standards.and sharing workshop.which was held virtually in early june.this workshop.addressed the standards infrastructure.and incentives required to promote and.enable sherry.of gwas summary statistics the workshop.brought together attendees that.represented diverse groups.of stakeholders including cohort.representatives summary statistics users.tool developers.resource providers journal editors and.funders.recommendations from the workshop.included improving the functionality of.the gewass catalog.platform for submitting and curating.summary statistics from gua studies.standardizing the reporting of summary.statistics and related.study data in a manner that is findable.accessible interoperable.and reproducible in other words fair.and linking g y summary statistics data.to other relevant data.sets and resources such as dbgap ega and.anvil.the recommendations of the workshop will.be shared in a white paper.that outlines the future of gwas data.sharing.the phenotypes and exposures or phoenix.toolkit is a catalog of consensus.protocols for measuring phenotypes and.exposures in biomedical research.with significant leadership and funding.support from the national institute on.minority health.and health disparities a new social.determinants of health assessments.collection.or sdoh was added to the phoenix toolkit.this collection contains 19 protocols to.help.measure factors that shape behaviors and.health outcomes.examples of the sdoh protocols include.concentrated.poverty access to health services and.technologies.spirituality and areas where junk food.outlets.outnumber healthy food options also.known as.food swamps this collection is expected.to provide a common currency for.studying social determinants of health.and can be used to examine health.inequities.the sdoh collection has been highlighted.in a recent and a number of covet 19.related funding notices.including that for the rapid.acceleration of diagnostics.underserved populations or rad x up.program.which seeks to understand factors that.have led to disproportionate burden.of the covet 19 pandemic on underserved.and or vulnerable populations.the electronic medical record in.genomics or emerge.network conducts groundbreaking research.on how to effectively use electronic.records and large biorepositories to.enable the integration of genomic.information into clinical care.this july the emerge genomic risk.assessment and management network was.launched.this five-year phase of emerge will.include 10 clinical sites.and a study coordinating center the.network also includes 15.clinical site partners and many.affiliates as shown on this map.the network aims to expand best.practices and knowledge and effective.implementation of genomic medicine.by understanding how genomics.contributes to an individual's.risk of developing disease.the emerge genomic risk assessment and.management network will apply.and validate polygenic risk scores or.prs.in diverse populations combine prs.results with family history and clinical.covariance.to determine genomic risk assessments.return results using electronic medical.record or emr.to 25 000 diverse participants.and assess uptake of risk reduction.recommendations and impact of related.clinical outcomes to better understand.genomic risk.in the broader u.s population.the clinical genome resource for clingen.evaluates and disseminates the clinical.relevance of genes and genomic variants.for use in precision medicine and.research.clingen's ancestry and diversity working.group collaborated with the clinical.sequencing evidence generating.research or caesar program to.investigate.clinical geneticist understanding and.use of the terms.race ethnicity and ancestry.in their work the study was recently.published in the american journal of.human genetics.the findings highlight a lack of.standard definitions and protocols for.the collection and use of diversity.measures.in clinical genetics and support the.need for standardizing.and harmonizing the collection of these.measures to understand their importance.in genomic medicine.and precision medicine.genome connect is clingen's online.patient registry where individuals can.securely share their genetic and health.information.for use by researchers and healthcare.providers.genome connect also provides.participants the ability.to share their genomic variant data with.clinvar to connect with others who have.similar genomic variants.to learn about additional research.opportunities and to receive.updates about the genomic test results.as of.april of this year 2998 participants.from 43 countries have consented.to participate in the registry and.nearly 1500 genomic variant.interpretations from de-identified.genome connect participant data have.been shared with clinvar.given genome connect's success in.engaging patients.in genomic data sharing the genome.connect team wanted to make those same.opportunities available.to patients participating in other.registries who are not currently sharing.data.to that end genome connect has launched.the patient data sharing program.thus far the nine registries shown here.on the right are participating.in this expanded program.the implementing genomics in practice or.ignite program.this consists of a network of five.clinical groups and a coordinating.center.which are together conducting pragmatic.clinical trials to study.the implementation of genomic medicine.in diverse studies.despite the unprecedented times related.to the covet 19 pandemic.the network recently launched the trial.genetic testing to understand.renal disease disparities across the u.s.or guard u.s the trial is studying.whether knowledge that a participant is.positive for a high-risk genomic variant.in apoll1.a gene associated with chronic kidney.disease.results in a change in blood pressure.management the study.aims to enroll over 5000.african-american participants.as high-risk apol1 genotypes are.disproportionately present in this.population.four clinical sites have been activated.with several more planned for activation.over the next few months.the first patient was randomized into.the trial in early july.and over 100 participants have been.enrolled so far.though covet 19 delayed site activation.enrollments by a few months.the ignite network is working to safely.and effectively recruit.participants into the study.this past june and july the new r01 and.r21 funding opportunities in genomic.medicine and genetic counseling were.published.the advancing genomic medicine research.opportunities.are soliciting applications that.stimulate innovation and advance.understanding of when where and how best.to implement genomic information and.technologies in clinical care.the first application due date was this.past august with the next due date in.march of 2021.and the last in march of 2023.the investigator initiated research on.genetic counseling processes and.practices opportunities.are soliciting applications to assess.strategies to optimize the counseling.process.in the context of limited resources the.first application due date is in october.with the second date in july of 2021..proposed projects for all funding.opportunities should be broadly.applicable to genomic medicine as a.field.and strongly encouraged to include.ancestrally diverse and.underrepresented participants and.populations.the ethical legal and social.implications or lc research program.supports research that anticipates.explores and addresses.implications of genomics for individuals.families.and communities nhgri along with nine.other nih institutes and centers and the.nih office of.behavioral and social sciences research.recently updated three.lc program announcements or pars.inviting a wide range of applications.for studying the ethical legal and.social implications of human genomics.research.for large multi-disciplinary studies.that are building on preliminary data.and require funding beyond two years.applicants should consider the lc r01.par.for small projects that are exploratory.in nature.or designed to generate pilot data.applicants should consider the lcr.21 par for very small projects such as.those involving single investigators.focused conceptual or analytical studies.or secondary data analyses.applicants should consider the lcro3.par of note the three annual application.due dates are different.from the standard nih due dates for all.three pars.the application due dates are in october.february and june.from february from 2021 through 2023.nhgri offers training and career.development support through a variety of.mechanisms.including individual fellowship and.career development awards institutional.awards.and diversity and re-entry supplements.our programs offer opportunities at the.undergraduate.post-baccalaureate graduate.post-doctoral.and faculty levels the program continues.to grow with new t-32 awards.the two the t-32 programs funded by nhri.date back to 1995..in fiscal year 2020 six t-32 programs.successfully renewed.shown in the first four the first six.rows of this table.the last row reflects the seventh t-32.that represents a new program.at the university of connecticut which.will support pre-doctoral scientists and.will focus on computational genomics.these seven training grants will.complement the 21 other.t32 programs currently funded by nhgri.and finally for nhgri the genomic.innovator awards support.creative and early career genomics.researchers who have played a key role.in consortia.or similar large team science efforts.the program provides flexible funding.that allows these investigators to.pursue highly innovative.research in all areas of genomics.relevant to nhgri's mission.nhgri recently announced the second set.of genomic innovator awards to the 12.promising investigators listed here the.grants will support a range of different.research projects.including the development of variety of.innovative tools and computational.methods for genomics research.an investigation of genomic variation in.american indian and alaska of native.people.and genes important for drug response.and studies related to the.implementation of genomic testing in.clinical settings.the next receipt date for this program.is october 30th.moving on then to the nih common fund.and other.trans-nih efforts.the library of integrated network-based.cellular signatures or.links is a common fund program intended.to create a network-based understanding.of biology by cataloging changes in gene.expression and other cellular processes.lynx uses computational tools to.integrate the diverse information for.the development.of new biomarkers and therapeutics.the lynx consortium will be holding its.final symposium.virtually on november 19th and 20th the.symposium will highlight achievements of.the links program.and individual centers over the past 10.years with presentations focusing on how.perturbation-based experiments are.providing new insights.into cell biology and drug discovery the.second half of the symposium will focus.on ways the scientific community can.access.links data and tools.the nih common fund recently released.four funding opportunity announcements.or foas.for the harnessing data science for.health discovery and innovation in.africa.or a dsi africa program.the new common fund program is designed.as a five five-year african-led.initiative.and is intended to build on previous.large-scale nih collaborations on the.continent.including the human heredity and health.in africa or h3 africa program.the dsi africa will leverage existing.data and technologies to develop.solutions for the continent's most.pressing.clinical and public health problems the.foas call for applications.in four different areas an open data.science platform a coordinating center.research hubs research training programs.and finally ethical legal and social.implications research.applications are due in late november.and early december.the human biomolecular atlas program or.hub map.is an nih common fund program that aims.to catalyze development of an open.global framework for comprehensively.mapping.the human body at cellular resolution.hub map insights will lead to better.understanding of the significance of.inner individual variability.changes across the lifespan tissue.engineering.and the emergence of disease at the.biomolecular level.hubmap's first data release occurred.earlier this month.these data were generated with healthy.tissues from seven organs.heart kidney large intestine lymph node.small intestine spleen and thymus.this release features a uniform data.analysis pipeline.applied on single cell transcriptomics.and epigenomic data.along with antibody based images the.release.also includes comprehensive metadata.that covers all aspects of labeling and.providence.including de-identified donor.information details of tissue.processing and protocols data levels and.processing pipelines.future releases are planned every six.months.pubmap held a functional proteomics.virtual workshop.last week the workshop focused on two.key questions how to.integrate analysis of proteomics and.transcriptomics data.and how to link single cell proto.proteomics data sets together.new awards will start in october of this.year which will almost double the number.of hub-map groups.and expand the number of organs being.studied significantly.last january the nih council of councils.approved a new.241 million dollar initiative.called the faculty institutional.recruitment for sustainable.transformation.or first program this is part of the nih.common fund.the overall objective of first is to.create cultures of inclusive excellence.at nih-funded institutions by.implementing a set of well-integrated.evidence-based strategies and then.evaluating their impact.on pre-specified metrics of.institutional culture.inclusion and diversity.last month nih released notice of intent.to publish.two funding opportunity announcements or.foas for the first program.one funding mechanism will provide.opportunities for institutions to.develop and implement faculty cohort.models for the simultaneous hiring.of a diverse group of faculty the second.funding mechanism will support a.coordination evaluation center to.facilitate consortium-wide activities.lead the development of evaluation.strategies and assess the impact and.outcomes.of the first program the estimated.publication date is september 9th and.the estimated application due date is.november 9th.nhgri strongly encourages investigators.in genomics research community.to apply to the first program.moving beyond the nih common fund.specifically to talk about the trans nih.all of us research program this program.of course is building.one of the largest biomedical resources.that utilizes volunteer participation.within the united states to represent.its population diversity.its aim is to gather data from one.million or more people living in the.united states to accelerate research.and improve the health of the nation.in partnership with the baylor college.of medicine's.human genome sequencing center the.center for inherited disease research.the broad institute the northwest.genomics center at university of.washington.partners healthcare and color genomics.the all of us research program has.started.generating genomic data the program.plans to perform.genotyping on over 200 000 samples.and whole genome sequencing on.approximately a hundred thousand samples.within the next year data curation.is being performed at the data and.research center using the broad.institute's terra platform.with the first data becoming available.in 2021.finally the fda's have now approved the.all of us.investigational device exemption in july.for return of select information on.hereditary disease risk.and pharmacogenomics.this past may all of us opened the.researcher workbench for beta testing.marking an important step in their.effort to engage the research community.and accelerate new discoveries the.initial data release features physical.measurements and data from surveys and.electronic health records.new data will be added about twice a.year and over time this will include.data from genomic analyses.from wearables and more the beta test.site is designed for researchers who can.code in r.or python the workbench includes a set.of tools to help build participant.cohorts.including data sets with customized sets.of medical concepts.a help desk and other resources are.available to enable researchers to.explore and interact.with the researcher workbench.environment.currently access is available to.researchers with era commons accounts.whose institutions have signed.a data use agreement with the program.you are encouraged to explore the.researcher workbench and learn how the.all of us resource can contribute to.your research.beta testers are also encouraged to.provide feedback to all of us.on how well the data tools and policies.are working.moving on to nhur activities and the.areas of communications.policy and education.nhgri's history of genomics program.recently announced the establishment of.a special postdoctoral fellowship.opportunity.to to conduct scholarly pursuits related.to the history of the field of genomics.this work will be conducted in.partnership with the institute's.intramural research program.specifically within the engagement.methods unit of the social behavioral.research branch.the selected fellow will produce.scholarly writings related to the.history of genomics.and pursue original research studies.with special emphasis on engagement with.diverse.and underserved groups.every summer nhgri's education and.community involvement branch.hosts its annual short course in.genomics.for this is a course for middle school.high school.community college and tribal college.science educators.in a typical year about 30 educators.travel to nih.to hear lectures and receive teaching.resources from nhgri and nih researchers.and clinicians and other staff.topics include genetic diseases dna.sequencing technologies bioinformatics.gene editing microbiome studies.and ethical issues in biomedical.research well.not surprisingly this year's course was.held in a virtual.format for the first time the.institute's communication and public.liaison branch pre-recorded key.course lectures and students were.provided articles hands-on materials and.other resources in advance of the course.more than two dozen educators.participated in the summer's short.course.all conducted by zoom.also during the summer the education and.community involvement branch worked.with the prince george's county maryland.youth career connect program.and the district of columbia's career.academics network.to support career preparedness and.science inquiry programming for high.school students.the students develop their professional.skills and telework etiquette while.simultaneously gaining exposure to a.variety of genomic careers.and applications of genomic technologies.branch staff also converted crispr and.dna sequencing hands-on activities into.virtual.engagement experiences for middle and.high school students.these new materials were used by two.stem virtual summer camps.offered by the local every girl can.learning institute.and the department of biological science.at the university of texas at.dallas.and finally moving on to nhgri's.intramural.research program in july the telomere to.telomere consortium co-led by.nhgri intramural investigator adam.philippi an nhgri grant grantee.karen miga of the university of.california in santa cruz.published a groundbreaking paper in the.journal nature which reported the.generation of the first.gapless end-to-end assembly of a human.chromosome sequence.specifically for the x chromosome the de.novo human chromosome sequence assembly.surpasses the continuity.of the best available human reference.genome sequence.the researchers were able to achieve.this feat by using high-coverage.ultra-long-read nanopore sequencing of a.complete hydadenoform mole.genome combined with complementary.technologies for quality improvement and.validation.to note this important milestone the.nhgri's communication and public liaison.branch developed.multiple products for various platforms.an interview with adam felipe garnered.thousands of views on youtube.and social media platforms the branch.also drove.a successful media coverage campaign.with a news release and press coverage.that was extensively picked up.another honor for an intramural.investigator charles rotimi.another senior investigator at.intramural research program.has been elected the 2022 president of.the american society of human genetics.charles is an nih distinguished.investigator director of the nih center.for research on genomics and global.health.and chief of nhgri's metabolic.cardiovascular inflammatory disease.genomics branch.congratulations to charles for this.honor.and then before closing let me remind.you that i can be followed on twitter.at nhgri underscore director where i.communicate regularly.about nhgri and genomics to various.stakeholders.and for those of you who want to hear.from me only just like maybe once a.month.you're welcome to sign up to receive my.monthly email update called the genomics.landscape.on nhgri's website genome.gov by.subscribing.under email updates.and finally a personal thanks to the.many nhgri staff members who contributed.to the slides.and associated materials that i just.reviewed in the past.hour or so for my director's report as.always.a group effort is essential for getting.such material together.and conveyed efficiently at each council.meeting.an additional thanks to the nhri.communications group and web team for.making my director's report into an.electronic resource.and then of course a special thanks to.the usual ringleader for helping me.prepare my director's report.chris what a strand is shown here in the.top row middle position.this is actually a screen capture from.one of the zoom-based video recordings.produced for celebrating the 30th.anniversary of the human genome project.launch.members of the nhgri history of genomics.program and communication and public.liaison branch.can be seen here preparing to videotape.mark o'mara of the university of british.columbia who's seen in the upper right.corner and with that i will stop.and pause and take any questions.that you might have.okay eric thank you very much i don't.see any hands going up.so we will move on.

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For taxes, does one have to fill out a federal IRS form and a state IRS form?

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Tamil Nadu has made it very clear in its prospectus this year. Candidates who have applied for NEET as a person from other state cannot claim nativity of Tamil Nadu. Below is a snapshot from the prospectus; read point (C).

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Individuals who don't own businesses spend tens of billions of dollars each year (in fees and time) filing taxes. Most of this is unnecessary. The government already has most of the information it asks us to provide. It knows what are wages are, how much interest we earn, and so on. It should provide the information it has on the right line of an electronic tax return it provides us or our accountant. Think about VISA. VISA doesn't send you a blank piece of paper each month, and ask you to list all your purchases, add them up and then penalize you if you get the wrong number. It sends you a statement with everything it knows on it. We are one of the only countries in the world that makes filing so hard. Many companies send you a tentative tax return, which you can adjust. Others have withholding at the source, so the average citizen doesn't file anything. California adopted a form of the above -- it was called ReadyReturn. 98%+ of those who tried it loved it. But the program was bitterly opposed by Intuit, makers of Turbo Tax. They went so far as to contribute $1 million to a PAC that made an independent expenditure for one candidate running for statewide office. The program was also opposed by Rush Limbaugh and Grover Norquist. The stated reason was that the government would cheat taxpayers. I believe the real reason is that they want tax filing to be painful, since they believe that acts as a constraint on government programs.

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